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This alpha-cell expansion has been associated with the development of pancreatic neuroendocrine tumors

Combination therapy with medications like phentermine/topiramate (Qsymia) or naltrexone/bupropion (Contrave) may benefit some patients, though evidence for combining these with GLP-1 agonists remains limited

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[55] This cascade alters cellular energy dynamics, ultimately triggering the influx of calcium into the cell, which prompts the exocytosis (release) of insulin-containing vesicles into the bloodstream

Update on cardiovascular risk and obesity in psoriatic arthritis