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Additionally, DMT1, cyclooxygenase 2 (COX2), and ACSL4 showed substantial increases in mRNA expression levels, whereas GPX4 decreased in the DSS group

Taken together, our results suggest that colistin-induced mitochondrial depolarization occurs primarily upon opening of the mPTP

The increase in rate coincides with a steeper diastolic depolarization potential, shortening of the action potential duration, and a shift in the leading pacemaker site, all changes previously associated with a variety of neurohumoral factors 6769 but here identified to be independent of these

in: PubMed | Google Scholar | 1 Ted Rogers Centre for Heart Research, University of Toronto, Toronto, Ontario, Canada