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Both combinations leverage cagrilintide's amylin pathway activation, but they differ significantly in their complementary mechanisms

Here's why the combination works better than either one alone

conceived of the idea, designed the study, contributed reagents/materials and wrote the manuscript

Liver immunohistochemistry was performed as previously described 54

This cleavage generates the Notch intracellular domain (NICD), which enters the nucleus to form a ternary complex with LAG-1, a CSL DNA-binding protein, and LAG-3/SEL-8, a Mastermind-like transcriptional co-activator

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