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Keywords: glutathione peroxidase 1, oxidative stress, selenium, selenocysteine, endothelial dysfunction, cardiac protection, angiogenesis, inflammation, atherosclerosis, stroke, neurodegeneration, cancer Graphical Abstract Glutathione peroxidase 1 (GPx1) is a member of a family of antioxidant enzymes that reduce hydrogen peroxide and soluble lipid hydroperoxides using glutathione (GSH) as a source of reducing equivalents 1

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