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Efficacy endpoints for semaglutide compared to placebo, stratified by obesity class at baseline, were assessed using both the full analysis set (all randomized participants according to the intention-to-treat principle, regardless of treatment discontinuation) and the on-treatment data (including only patients receiving allocated study medication)

Even small changes in absorption may lead to suboptimal outcomes or increased side effects

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Branched-Chain Amino Acid (BCAA) Metabolism The branched-chain amino acids (BCAAs)leucine, isoleucine, and valineare essential amino acids for mammals

The exact reason Ozempic causes diarrhea remains unclear, but researchers believe it is related to how semaglutide alters digestion