how was glp-1 discovered Xenopus GLP-1-inspired discovery of novel receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential JCI - The GLP-1 journey:

Current evidence suggests that dysregulated T-cell responses and antigen recognition of neuronal proteins may contribute to disease processes, although the extent and significance of these effects require further investigation [80]

doi: 10.3389/fcell.2020.588050 238 KimMHKwonSYWooSYSeoWDKimDY

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Preclinical studies and clinical trials suggest that antioxidants, such as small thiol molecules (N-acetyl-L-cysteine and carbocysteine), antioxidant enzymes (glutathione peroxidases), activators of Nrf2-regulated antioxidant defense system (sulforaphane), and vitamins, for example, C, E, and D, enhance the endogenous antioxidant system and reduce oxidative stress

[DOI] [PubMed] [Google Scholar] 8.Fournier KA, Hass CJ, Naik SK, Lodha N, Cauraugh JH