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Until stereoisomer-specific studies and formal pharmacovigilance data are available, any long-term or high-dose use carries unknown risk

doi: 10.1016/j.dental.2013.11.014 9 BowenW

Because glutamate signalling is ubiquitous in the brain (and concentrated in other tissues such as the heart, adrenal glands and the gastrointestinal tract Julio-Pieper et al 2011) this neuroinflammatory cycle can result in a wide range of symptoms that then result in a variety of differential diagnoses

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