Slow-wave sleep is the stage during which growth hormone peaks, insulin sensitivity improves, and cortisol drops to its daily nadir
Schedule comprehensive bloodwork including a complete metabolic panel (CMP), thyroid function tests (TSH, free T3, free T4), and inflammatory markers (CRP, IL-6 if accessible)
Interestingly, GPx3 was identified as the sole protein with the most significant reduction in signal for children affected with konzo, a finding that was further validated using ELISA as a secondary method of confirmation
Elife (2022) 11:e74549
Konig SA, Siemes H, Blaker F, Boenigk E, Gross-Selbeck G, Hanefeld F, Haas N, Kohler B, Koelfen W, Korinthenberg R: Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities