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This novel approach to melanocortin receptor selectivity for weight loss was informed by our previous work demonstrating that co-administration of an MC4R-selective agonist and an MC3R-selective agonist caused a greater reduction in food intake and body weight in DIO NHPs than administration of either compound alone, yielding 7.8% weight loss after 36 days (25)

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Nausea was generally mild to moderate and typically resolved over time

Key differences in titration approach All three medications use monthly dose increases

Other Information: Recyclable Container