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With semaglutide: up to 20.4% over 68 weeks

A 2023 review published in Nutrients highlighted the importance of dietary protein in mitigating sarcopenia (muscle loss) in individuals undergoing bariatric surgery or medical weight management, a principle directly applicable to GLP-1 therapy users

Nat Rev Immunol 23 , 720734 (2023)

However, several things can inhibit the secretion of intrinsic factors, which in turn decreases the absorption of B12 by around half per dose, regardless of how high the overall dosage level is given

Healthcare providers will usually do blood tests to check for B12 deficiency in people who have a high risk of developing it