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TGR5 agonists are promising therapeutic agents for treating gout (as summarized in Table 1 )

Semaglutide and Tirzepatide otherwise known as skinny shots are injectable medications that have revolutionized the field of weight management and diabetes treatment

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A recent case report of a young woman born with generalized congenital dermal melanocytosis who subsequently developed bilateral nevus of Ota and eruptive blue nevi highlights this association [69]

The candidate will be developed as both an oral formulation (PN-477o) for once-daily dosing and a subcutaneous version (PN-477sc) for once-weekly injections