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Results vary by individual and by the peptides prescribed, and side effects are relatively uncommon and usually mild

A large retrospective analysis of more than 4,000 adults found that sublingual B12 raised blood B12 levels at least as effectively as intramuscular injections over the period studied (Bensky and colleagues, 2019, DOI)

[46] [48] Pathophysiology [edit] Although the healthy body stores three to five years' worth of B 12 in the liver, the usually undetected autoimmune activity in one's gut over a prolonged period of time leads to B 12 depletion and the resulting anemia

Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )