10.1038/nrn3921 [DOI] [PMC free article] [PubMed] [Google Scholar] McClean, P
doi: 10.3390/molecules21091216 144
Avoid overly aggressive calorie restriction : Do not drop below 1,000 to 1,200 calories per day for women or 1,200 to 1,500 for men
Full disclaimer 1.AOD-9604 is a 16-amino acid peptide fragment derived from human growth hormone (hGH residues 177-191) with added tyrosine, developed by Metabolic Pharmaceuticals for obesity treatment 2.Proposed mechanism: selective stimulation of lipolysis (fat breakdown) and inhibition of lipogenesis (fat formation) without growth hormone-like effects on IGF-1 or blood glucose 3.Failed Phase 2b clinical trial for obesity (2007)did not demonstrate statistically significant weight loss versus placebo, terminating clinical development for this indication 4.Received FDA "Generally Recognized as Safe" (GRAS) designation in 2023 as a food substance, but this is NOT a drug approval and does not establish efficacy for weight loss 5.Regulatory status: not FDA-approved as a drug, prohibited by WADA, and insufficient evidence for weight loss efficacy
The cabbage slaw provides crunch, fiber, and probiotics that support the gut health changes happening on GLP-1 medications
