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4 Discussion The severe insulin resistance, hepatic steatosis, dyslipidaemia and hyperphagia that characterises lipodystrophy makes effective treatment challenging and limits the effectiveness of commonly used diabetes therapies ( BSCL2 ( The data presented indicate that liraglutide improves lipoatrophic diabetes in SKO mice, with both improvements to insulin sensitivity and enhanced glucose regulated insulin release

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In: The Journal of physiology 591 (18), S