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Table 3 summarizes the pooled data on the gastrointestinal adverse reactions observed in the SURPASS-1 to SURPASS-5 studies for T2D therapy in comparison to placebo (61)

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Safety assessments comprised of treatment-emergent adverse events (TEAEs), laboratory tests, physical examinations and medical as- sessments, vital signs, electrocardiogram (ECG) parameters, body weight, and hypoglycemia events (dened below)

Generally, candidates for this treatment have struggled to lose weight through diet and exercise alone and are looking for a medically supervised path to achieving a healthier body composition

The effects of ZAG on adipose tissue metabolism may also be mediated through a positive influence on adiponectin expression [96]