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Understanding Constipation on GLP-1 Medications Constipation on GLP-1 is a common issue because these medications slow digestion

The most common side effects, such as injection site reactions, water retention, and flushing, are typically transient and resolve on their own or with adjustments to the protocol

These inflammatory signals not only cause local mucosal barrier dysfunction and increased intestinal permeability but can also be transmitted to the CNS via humoral circulation or the vagus nerve