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This pathway provides a lipid radical-trapping mechanism at the plasma membrane ( - (e.g., erastin and its derivatives), direct inhibition of GPX4 (e.g., RSL3), or disruption of the FSP1-CoQ10 axis ( Conversely, iron chelation strategies, using agents such as deferiprone, deferoxamine, and deferasirox, may be beneficial in early-stage or iron-addicted tumours by limiting proliferation and reducing oxidative damage to surrounding tissues ( Figure 4 ) ( Breast cancer metastasis Metastasis involves the spread of cancer cells from the site of tumorigenesis to nearby tissues or organs (113)

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