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Medical treatments often provide suboptimal ICP reduction and are frequently limited by poor tolerability

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Such examples demonstrate the potential of OoC systems to become a fast, reliable and ethically appropriate approach for drug testing in detriment of conventional in vivo models (57)

For instance, in pancreatic ductal carcinoma (51), Gln deprivation promotes EMT progression and metastasis, whereas in ovarian cancer, Gln deprivation inhibits the cells ability to migrate and invade

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