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In the UKPDS cohort, the development of eGFR 300 mg/g) as the main renal outcome and the other trials addressing also eGFR-related endpoints, RRT and renal death (Table 1) [11]

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Adverse Effects The most frequently reported side effects are nausea and vomiting (up to 40% of patients), which may be minimized by administration of smaller and more frequent doses