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Therefore, ApoA-I, the main carrier protein of HDL, is critical to reverse the cholesterol transport process which is the pathway by which excess peripheral cholesterol is returned to the liver, and plays a crucial role in the cellular cholesterol efflux capacity (CEC) mechanism

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The same kind of shedding can happen after bariatric surgery or any major weight loss

If left untreated, within 2 years, this disease would progress to biliary fibrosis and eventual hepatic failure requiring liver transplantation

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