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Its the more recent anti-obesity drugs, such as semaglutide (Ozempic and Rybelsus for diabetes, Wegovy for obesity) and tirzepatide (a dual GLP-1 and GIP agonist

The speed of the development pipeline only adds to the challenge as GLP1 therapies are being used for approved indications beyond diabetes and obesity, including heart, liver and renal disease. With these evolving usage patterns, plan sponsors face a coverage dilemma defined by constant change and escalating financial exposure

Thus, although much research is focused on defining the direct intrakidney effects of GLP-1 receptor agonists, it is possible that some of the benefits occur indirectly, as a result of GLP-1 receptor agonists ability to improve kidney risk factors, as well as via extrarenal systemic effects of these agents that are not yet fully defined, such as attenuation of low-grade systemic inflammation

It works on both the GIP and GLP-1 receptor pathways, which is why many patients group it with GLP-1 weight-loss injections

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