The obesity and diabetes medication tirzepatide (Mounjaro, Zepbound) reduced obstructive sleep apnea events by as much as two-thirds in new clinical trials
DPP4 have demonstrated anti hyperglycemic efficacy of DPP4 inhibitors alone or in combination, with mean change in Hb1ac-3 to -19 mmol/mol (-0.3 to -1.7%) without excess risk of hypoglycemia or weight gain (Figure 2)
Who Should Avoid This Combination and Provider Evaluation Criteria Individuals with severe kidney disease (eGFR less than 30 mL/min/1.73m), acute liver injury, uncontrolled hypoglycemia, or a history of pancreatitis should not use GLP-1 and berberine together without specialist evaluation
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Secretagogues are part of a complex therapy that works in the same way as the hormones they replace stimulating the production of other such chemical messengers in the body