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To date, all CVOTs for dipeptidyl peptidase 4 (DPP-4) inhibitors, 4-7 glucagon-like peptide-1 receptor agonists (GLP-1 RAs), 8-13 and sodium-glucose transport protein 2 (SGLT-2) inhibitors 14-16 have documented a lack of increased CV risk (non-inferiority) with the investigational product in patients with T2DM compared to placebo

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