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Common side effects include increased urination, genital thrush, and a small risk of diabetic ketoacidosis, particularly during illness

If you can access it through insurance, a savings program, or affordable compounding options , tirzepatide is the more effective choice for most patients seeking significant weight loss

A patient with specific GIPR or GLP1R variants may benefit from dual-agonist formulations (like tirzepatide) or microdose protocols, whereas standard escalation schedules might not optimize outcomes for their biology

In addition to a decrease in peripheral levels of LAC, LAC levels are decreased by 4060% in the hippocampus and prefrontal cortex of rodents with depressive-like behaviors, including the Flinders Sensitive Line (FSL) rats [30]