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Importantly, all reported adverse effects were mild in nature, with no serious adverse reactions attributed to curcumin administration in any of the included trials
In another double-blind, placebo-controlled trial, an improvement in cognitive performance (i.e., MMSE score) was reported in AD patients randomized to receive 800 IU/day of all - rac --tocopherol (360 mg/day of RRR --tocopherol) for six months only when the treatment effectively reduced oxidative stress (as assessed by the measure of total glutathione and markers of lipid peroxidation in the blood) (110)
One notable trial in 20 subjects compared the effects of the retinoid tretinoin, which is about 10x more potent than retinol, to the effects of GHK-Cu on dermal procollagen synthesis, epidermal proliferation, and inflammation
These reactions are mediated by the IgE pathway which results in an immediate reaction and the following recommendations do NOT apply for those reactions
KCl can be given in the same line with lipid and ammonia scavengers, weak recommendation, low quality evidence (2C)
