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Secondly, TSH predominantly reflects pituitary sensitivity to circulating T4, rather than tissue-specific availability or utilisation of the active hormone T3

The clinical target is a fat-to-lean-loss ratio of at least 3:1, meaning at least 75% of total weight lost should be fat mass, not lean tissue

If side effects are mild and the patient is losing weight as expected, the doctor might maintain the dosage

If storing many packs, space them out to reduce the chance of a chain reaction if one fails

Although the medication can lead to significant weight loss, it works best when combined with lifestyle changes such as diet and exercise