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Weight cycling and its effects on muscle mass, sarcopenia and sarcopenic obesity

The Journal of biological chemistry 276 (52): 4896748972

BPC-157, a stable gastric pentadecapeptide, works primarily through angiogenic (blood vessel formation) and nitric oxide pathways, showing particular efficacy in gastrointestinal, tendon, and ligament healing in animal models

GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)

The staff has advised against allowing for broader pharmacy compounding of the seven peptides, saying there is scant evidence to support their safety and effectiveness