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Smad7 is an inhibitory Smad that binds to the TGF- receptor to block Smad2 and Smad3 from binding, therefore inhibiting the TGF-/Smad signaling cascade

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Originally identified during investigations involving sleep physiology and neurological regulation, DSIP peptide has attracted substantial scientific interest due to its unique structure and potential interactions with biological systems associated with sleep cycles and neuroendocrine signaling