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Concurrently, expression of beta cell identity and function markers, including Neurod1 , Pax6 , Slc30a8 , Iapp , Mafa , Gck and Trpm5 , was significantly reduced in 17-week-old untreated mice, indicating progressive beta cell dedifferentiation/dysfunction

Tissue Inhibitor of Metalloproteinase (TIMP) Interactions The balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), determines net proteolytic activity in tissues

But here is the critical distinction