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Depletion of cellular glutathione concentration during cell proliferation Cellular glutathione concentration fell progressively during the culture (as previously reported, in reference [24])

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When glutathione levels are low, deiodinase activity is impaired, potentially reducing T4-to-T3 conversion and contributing to symptoms of hypothyroidism even when TSH and T4 levels appear normal - a pattern frequently reported by patients with Hashimoto's thyroiditis