Reduced food intake and shifts toward lower-calorie options alter bacterial populations, temporarily reducing the production of short-chain fatty acids that help regulate bowel consistency
Drinking plenty of water, keeping blood sugar levels steady, and checking thyroid levels when needed are also good steps to avoid complications
Patients should receive counselling from a registered dietitian to ensure their reduced-calorie diet includes: Haem iron sources : lean red meat, poultry, fish (more readily absorbed) Non-haem iron sources : fortified cereals, beans, lentils, dark leafy greens, dried fruit Absorption enhancers : vitamin C-rich foods consumed with iron sources Avoidance of inhibitors : limiting tea, coffee, and calcium supplements around iron-rich meals Iron supplementation may be necessary if dietary measures prove insufficient or if deficiency develops
1,500 participants will be recruited by using the same criteria as those of TRAILBLAZER-ALZ 2 from 148 sites across China, Korea, Taiwan, and Europe
However, fever, severe nausea, or inability to maintain hydration significantly raises safety concerns and warrants immediate provider communication to assess continuation
