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While there are typically no serious systemic effects (because the patches are largely inactive), the ingredients are not standardized and may contain undisclosed chemicals or allergens

2024;22(1):8 Effect of GLP-1 agonist on improving cardiovascular function through improving liver function

Retatrutide is an investigational peptide that acts as a triple receptor agonist, targeting the GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), and glucagon receptors