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[1] [4] Immediate disposal is required if: The solution appears cloudy, discolored, or contains particles The pen has been frozen at any point The pen has been exposed to temperatures above 86F The pen has been shaken vigorously The pen is cracked, damaged, or malfunctioning The pen has been stored improperly and the duration of improper storage is unknown An unused pen has been out of refrigeration for more than 21 days Proper disposal follows FDA guidelines for injectable medications

These selective therapies can also be targeted to act specifically in immune cells within the TME [176], avoiding their antagonistic and undesired effects when affecting other cells, like tumor cells

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--- The Dosing Protocol The study used a locally administered protocol, injecting near the joint rather than systemic subcutaneous injection