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The important caveats on the topical data Honesty requires naming the limitations even of the route that does have human data

Vitamin B12 injections are generally safe, but some individuals may experience side effects, including: Pain or redness at the injection site Mild diarrhea Itching Nausea or vomiting Dizziness or headaches Hot flashes In rare cases, more serious reactions, such as allergic responses (rash, swelling, trouble breathing), can occur

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in: PubMed | Google Scholar | 1 Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

Biochemical Pharmacology