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Designed based on an in-depth understanding of incretin biology, tirzepatide can simultaneously activate GLP-1 and GIP receptors, thereby exerting synergistic effects that translate into superior outcomes in glycemic control, body weight management, and pancreatic -cell function preservation ( Evidence from the SURPASS phase III clinical trial program has consistently demonstrated the superior metabolic efficacy of tirzepatide compared with currently available GLP-1 receptor agonists, such as semaglutide

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