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In diabetic cardiomyopathy, the autophagy pathway may be inhibited, which leads to the accumulation of harmful substances in cardiomyocytes

Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ

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Nasal delivery eliminates the depot effect, meaning the peptide clears from circulation much faster

GLP-1 receptor agonists also exert antioxidant, anti-inflammatory, and antifibrotic effects by downregulating pro-inflammatory pathways (e.g., nuclear factor-B), cytokines (e.g., transforming growth factor ), and T-cell proliferation [18]