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The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes

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There is also a reason the combination is difficult to test cleanly: because both compounds act on overlapping repair pathways (angiogenesis, cell migration), a study of the two together struggles to attribute any observed effect to either one

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Usuda H, Okamoto T, Wada K