Once opened, tirzepatide can be kept at room temperature for up to 21 days, which offers flexibility for those who may not have immediate access to refrigeration
Higher doses cost more but remain well below retail pharmacy pricing at every level
It does not, however, replace the usual procedure of debridement, tetanus antitoxin, penicillin, tracheotomy, attention to fluid balance, and supportive care
When initiating tirzepatide in patients with pre-existing diabetic retinopathy, consideration should be given to ophthalmologic evaluation within 3-6 months if significant glycemic improvement is anticipated, though this represents expert opinion rather than specific guideline recommendations
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