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Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

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doi: 10.1681/ASN.2021081112 164 LuoYHLuoLWampflerJAWangYLiuDChenYMet al