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Mechanistically, liraglutide administration inhibited the upregulation of pain-related markers in the TNC, including calcitonin gene-related peptide (CGRP), c-fos, and components of the PI3K/Akt signaling pathway [94]

Visceral adiposity, insulin resistance, inflammation

And because the medications work by altering appetite signals, discontinuation frequently leads to weight regain, which highlights the importance of longterm planning and supportive lifestyle changes

[4] Ongoing and future trials are investigating their long-term efficacy and safety profiles, with a focus on cost, patient adherence, and side effects

[1] This sensation typically relates to the physiological changes that occur during significant weight loss rather than a direct pharmacological effect of the medication itself