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IVW combines SNP-specific estimates calculated using Wald ratios, assuming no directional pleiotropy of each SNP ( 2.4.2 Mediation analysis A two-step MR analysis (product of coefficients method) was applied to assess mediation ( Supplementary Figure 1

Of note, the role as loss of -arrestin-1 does not affect GLP-1R internalization on the other hand, enhancing -arrestin-2 action by the overexpression of G protein receptor kinase 5 (GRK5) increases GLP-1R endocytosis [53]

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