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Safety, Provider Oversight, and Who Should Consider Compounded GLP-1 Compounded semaglutide carries the same safety profile and contraindications as branded formulations: medullary thyroid carcinoma history, Type 1 diabetes, pancreatitis risk, and pregnancy require provider evaluation

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The risk of MACE was reduced by 12% (HR 0.88, 95% CI 0.840.94) with GLP-1RAs and by 11% (HR 0.89, 95% CI 0.830.96) with SGLT2is compared with that in placebo groups, suggesting that GLP-1RAs and SGLT2is reduce the risk of MACE to a similar extent

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Cortisol and ACTH are hormones potentially involved in the stress response and are typically associated with various metabolic and immune actions