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doi: 10.1016/j.celrep.2021.109235 156 WangBSunJMaYWuGShiYLeG

They generate oxidative stress, which has an effect on various age-related disorders and diseases

Biologically active compounds can also comprehensively regulate several PCD processes to reduce the damage to normal PCD in the body caused by H

FIGURE 10 Notably, activators of SIRT1, such as metformin, have demonstrated the ability to inhibit Th17 cell differentiation and downregulate IL-17A and RORt levels by promoting STAT3 deacetylation ( In summary, our study primarily investigated the beneficial effects of GHK-Cu in UC, using a DSS-induced colitis mouse model and an in vitro co-culture system, suggesting that GHK-Cu may exert anti-inflammatory properties and its role in facilitating the repair of UC by regulating SIRT1/STAT3 signaling pathway

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