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However, the evidence is limited in size and duration, and risks during early postpartum or with oral formulations remain less clear

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Moreover, studies have shown that atherosclerosis usually precedes ischemic heart disease (Panizzi et al., 2010), and that atherosclerosis induces myocardial infarction, which leads to a drastic reduction in myocardial contractility, dilation of the left ventricle, and a significant reduction in the hearts pumping capacity, which can easily lead to heart failure (Swirski and Nahrendorf, 2013)

10.3390/ani15020204 [DOI] [PMC free article] [PubMed] [Google Scholar] Tamrakar S

For those denied GLP-1 coverage altogether, other oral alternatives like Qsymia and Contrave may be worth exploring