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Opioid abusers who must undergo surgery need to achieve concentrations of opioids in the same range as treatment-resistant, chronic abusers [137], underscoring the fact that patients with different drug histories may have different physiological responses to identical drug dosages

In conclusion, an imbalance in redox reactions is only one of the many factors contributing to ASD, and further studies are necessary to investigate other factors, such as impaired neurotransmission, immune dysregulation in the brain, and mitochondrial dysfunction

10.1016/j.pmpp.2015.09.001 71 HoG

Statistical significance was assessed by by ordinary two-way ANOVA in a , and by unpaired two-tailed t-test in b , c