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An earlier Phase 3 trial in people with obesity and knee osteoarthritis, TRIUMPH-4, found an average weight loss of 28.7% at the same dose, alongside a reduction in joint pain

Research documents that endothelial cells at injury sites produce SPARC protein containing GHK sequences, which upon breakdown releases GHK-containing peptides that stimulate cell proliferation and new vessel growth

doi: 10.1038/nbt.4072 101 Tabula Muris Consortium