Some individuals report nausea, heartburn, or gastrointestinal discomfort when starting GLP-1 therapy, which may interfere with falling or staying asleep
Inside that overarching trial, Lilly nested two "basket" sub-studies to test whether the weight loss would carry specific obesity comorbidities with it: Knee osteoarthritis basket: 574 participants with symptomatic knee OA Obstructive sleep apnea basket: 243 participants with moderate-to-severe OSA The design matters
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As weight drops and metabolic health improves, overall energy increases
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