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Although the release of these proteins into the cytosol is expected to trigger apoptosis, this form of cell death is negligible in APAP-induced hepatotoxicity, as shown by the absence of caspases activation and the inability of caspase inhibitors to protect against APAP-induced liver injury (Jaeschke et al., 2006)

Rothstein JD, Van Kammen M, Levey AI, et al

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The reduced food intake that comes with appetite suppression adds another layer

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