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Furthermore, these haplotype associations require further analysis to exclude nearby HLA gene variantswhich may influence the observed immune phenotype due to linkage disequilibrium with specific C4 alleles ( 5 Potential pathophysiological mechanisms of toll-like receptors and gut bacterial translocation in schizophrenia and psychiatric disorders Toll-like receptors (TLRs) coordinate the activation of innate immune responses alongside the complement system and play a significant role in the neuroimmune mechanisms of schizophrenia

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(2011) 301:G1G8