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Less than 5% of clinical trial participants discontinued semaglutide due to side effects

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Dysfunction in endothelial cells is characterized by a reduced ability to dilate blood vessels due to decreased availability of nitric oxide, dysregulated angiogenesis, increased inflammatory adhesion molecules, permeability, and low-density lipoprotein oxidation [28]

While their benefits are well-documented, it is essential to understand the potential side effects and how to manage them effectively

The safest path is through a physician-led program that includes a full medical workup, lab monitoring, and ongoing follow-up